Something strange is happening in the small mountain town of Serenity, Tennessee. People going on routine errands never reach their destination. It's as if they simply disappear. Over the past few weeks, it's happened to five men and women, and now a child. The local police chief calls the FBI, and a team from the Special Crimes Unit is immediately sent in. Agents Lucas and Samantha Jordan, partners in work and in life, have very different abilities. Samantha is clairvoyant and Lucas possesses a unique ability to find the lost or abducted. With them are new partners Dante Swann, a medium, and Robbie Hodge, a telepath. The town is already on the edge of panic, but the mysterious events take a sinister turn when a body unrelated to the missing person's case surfaces and one of the SCU agents vanishes. Now, the team's hunt for the lost has turned into something very personal, and very dangerous.