The Philadelphia chromosome
a mutant gene and the quest to cure cancer at the genetic level
The Philadelphia chromosome
a mutant gene and the quest to cure cancer at the genetic level
Book - 2013
This work focuses on what is widely viewed as the 'poster child' of rational drug development in the cancer research world. The history of the founding of a genetic mutant chromosome in the indication of Chronic myeloid leukemia disease, and the subsequent development of "Gleevec," is the keynote of this astounding publication.
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| Barcode | Status | Material Type | CallNumber |
|---|---|---|---|
| 37413313511240 | متاح | Non-fiction | 616.9941 WAPNER |
| المؤلف الرئيسي: | |
|---|---|
| مؤلفون آخرون: | |
| التنسيق: | كتاب |
| اللغة: | English |
| منشور في: |
New York, NY :
The Experiment, LLC : Distributed by Workman Pub. Co.,
2013.
|
| الموضوعات: |
Search Result 1
The Philadelphia Chromosome
A mutant gene and the quest to cure cancer at the genetic level
Electronic Audio
حسب Wapner, Jessica
منشور في 2013
منشور في 2013
MARC
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| 100 | 1 | |a Wapner, Jessica. | |
| 245 | 1 | 4 | |a The Philadelphia chromosome : |b a mutant gene and the quest to cure cancer at the genetic level / |c Jessica Wapner ; foreword by Robert A. Weinberg. |
| 260 | |a New York, NY : |b The Experiment, LLC : |b Distributed by Workman Pub. Co., |c 2013. | ||
| 300 | |a xiii, 303 p., [8] p. of plates : |b ill. (some col.) ; |c 24 cm. | ||
| 500 | |a "This book draws extensively from interviews [the author] conducted with those who lived this story. Chronic myeloid leukemia (CML), the blood cancer that is this book's focus, is alternately referred to as chronic myelogenous leukemia."--Author's note. | ||
| 504 | |a Includes bibliographical references (p. 283-290) and index. | ||
| 505 | 0 | |a Down to the bone : February 2012 -- The chromosome and the disease : 1959-1990. The first clue ; Three hundred words ; Investigating a chicken virus ; Right number, wrong place ; The surprising source of the chicken cancer gene ; Consummate instigators ; Where the kinase hangs the keys ; A chemical amputation ; Stripping away the fur and the fat ; A funny new protein ; The first sign of a human cancer gene ; Spelling out the translocation ; "That word is oncogenes" -- Rational design : 1983-1998. Becoming a doctor, and then a scientist ; Turning a protein into a drug target ; A machine with a virus for a motor ; Plucking the low-hanging fruit ; A drug in search of a disease; Two endings ; Getting out of Boston ; Killing cells ; Gain and loss ; "Not over my dead body will this compound go into man" -- Human trials : 1998-2001. The quickest answer ; Getting to 200 milligrams ; The one thing they didn't have ; Buzz in the chat rooms ; Saving their own lives ; A response rate of one hundred percent ; Good stressful ; Putting it in writing ; A truckload of data ; The fathers of victory -- Aftermath. A price to pay ; Showing a weakness ; The first five years ; The second generation ; A Gleevec for every cancer -- Survival time. | |
| 520 | |a This work focuses on what is widely viewed as the 'poster child' of rational drug development in the cancer research world. The history of the founding of a genetic mutant chromosome in the indication of Chronic myeloid leukemia disease, and the subsequent development of "Gleevec," is the keynote of this astounding publication. | ||
| 650 | 0 | |a Chronic myeloid leukemia |x History. | |
| 650 | 0 | |a Chronic myeloid leukemia |x Genetic aspects. | |
| 650 | 0 | |a Cancer |x Genetic aspects. | |
| 650 | 0 | |a Cancer |x Research. | |
| 650 | 0 | |a Mutation (Biology) | |
| 650 | 0 | |a Imatinib. | |
| 600 | 1 | 0 | |a Hungerford, David S., |d 1938- |
| 700 | 1 | |a Weinberg, Robert A. |q (Robert Allan), |d 1942- | |
| 998 | |a 2013.05.16 | ||
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| 952 | f | f | |p Standard Circulation |a City of Spokane |b Spokane Public Library |c Branches |d Central |t 0 |e 616.9941 WAPNER |h Dewey Decimal classification |i Non-fiction |m 37413313511240 |