"A brother is as easily forgotten as an umbrella." James Joyce, Ulysses. Recently having abandoned his RD Laing-influenced experiment in running a therapeutic community - the so-called Concept House in Willesden - maverick psychiatrist Zack Busner arrives at Friern Hospital, a vast Victorian mental asylum in North London, under a professional and a marital cloud. He has every intention of avoiding controversy, but then he encounters Audrey Dearth, a working-class girl from Fulham born in 1890 who has been immured in Friern for decades. A socialist, a feminist and a munitions worker at the Woolwich Arsenal, Audrey fell victim to the encephalitis lethargica sleeping sickness epidemic at the end of the First World War and, like one of the subjects in Oliver Sacks' Awakenings, has been in a coma ever since. Realizing that Audrey is just one of a number of post-encephalitics scattered throughout the asylum, Busner becomes involved in an attempt to bring them back to life - with wholly unforeseen consequences.