When an experimental drug trial goes horribly wrong, seven young test subjects, after being kept awake for days, must face the terrifying side effect of the drug: if you fall asleep you die. Trapped in an isolated medical facility, they desperately try to find a way to reverse the side effects of the trial, as one by one they succumb to sleep and death. Panic quickly takes hold and they to turn on each other. It's left up to Claire, the group's unlikely leader, to keep them together, find a way to escape, and somehow manage to stay awake.