Neville is essentially the last man on earth, and the loneliness of his situation is the central part of the story. We gradually acquire the story of the deaths of Neville's wife and daughter, essentially experiencing the pain he goes through when these memories overcome him. We watch him drink himself into a stupor as each night finds him besieged in his fortified house, surrounded by vampires, including his old friend and neighbor, calling for him to come out. We watch him slowly lose his grip on sanity and come very close to giving up.